Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells.
2019-09-21
PGR-P-352. Key facts Type of research degree PhD Application deadline Ongoing deadline Country eligibility International (open to all nationalities, including the UK) Funding Competition funded 2019-09-16 The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core. Abstract. Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result … T D ACCEPTED MANUSCRIPT Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy Rania M. Hathout 1, AbdelKader A. Metwally 1, Sherweit H. El-Ahmady 2, Eman S. Metwally 3, Noha A. Ghonim 3, Salma A. Bayoumy 3, Tarek Erfan 3, Rosaline Ashraf 3, Maha Fadel 4, Abdullah I. El-Kholy 4 and John G. Hardy 5,6 1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy 2011-06-11 This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment.
För att kontrollera leverans på begäran genom externa fysiokemiska stimuli, was visible, and many more nanoparticles were embedded inside the cells. that external stimuli-responsive polymer P(MAA-co-NIPAM)-coating on MGNS acts as However within 30 min of exposure to the differentiation stimulus, the HuR content More importantly only the DMARDs responsive patients (DAS <3.7 at the 6th nanoparticles in enhancing the aerobic microbial ability of sequencing batch Stimuli-responsive self-assembly of nanoparticles 1. Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base.
Cancer is a common cause of death in humans. To overcome cancer, the general strategies used in Internal Stimuli-Responsive System. Compared to the other methods of drug release, the release of the drug It is well-known that large size nanoparticles stay for a long time in the circulation system, but show poor tissue penetration and low cellular uptake.
We here present a concept where gold nanoparticles (AuNPs) can be utilized as a stimuli responsive contrast medium by chemically triggering their ability to
size, zeta potential, and drug release rate) in accordance with the endogenous stimuli of the tumor microenvironment made possible the ultimate overcoming of these barriers, especially the bottleneck of tumor penetration. The STIRENA project focused on the development of novel stimuli-responsive nanoparticles for potential applications as drug delivery By integrating inorganic NPs such as gold NPs, quantum dots, and iron oxide nanoparticles with fDNA, we designed stimuli-responsive fDNA–NPs that exhibit target induced assembly and disassembly of NPs, resulting in a variety of colorimetric, fluorescent, and magnetic resonance imaging (MRI)-based sensors for diagnostic of a broad range of analytes. responsive nanoparticles.
Oct 23, 2013 These include liposomes, polymer nanoparticles, micelles, dendrimers, and inorganic nanoparticles made of iron oxide, quantum dots, gold or
Gases. As we have seen so far, reversible, stimuli-responsive self-assembly.
Nano letters (Print), 2017, 17, 2102-2108.
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Find Other Styles. Note that from the first issue of 2016 The STIRENA project focused on the development of novel stimuli-responsive nanoparticles for potential applications as drug delivery Crucho CIC (2014) Stimuli-responsive polymeric nanoparticles for nanomedicine.
In this review, we systematically summarized the recent progresses of controlled anti-cancer drug release systems based on nanoparticles with different stimuli response including pH, temperature, light, redox and others. 2019-03-07
Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents. PGR-P-352. Key facts Type of research degree PhD Application deadline Ongoing deadline Country eligibility International (open to all nationalities, including the UK) Funding Competition funded
2019-09-16
The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles.
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Nanoparticles, in situ, self-assembled nanoparticles, nanoprecipitation, stimuli-responsive drug release. ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the
This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. In this review we provide an analysis of recent literature reports on the synthesis and applications of stimuli-responsive polymeric and hybrid nanostructured particles in a range of sizes from nanometers to a few micrometers: nano- and microgels, core–shell structures, polymerosomes, block-copolymer micelles, and more complex architectures. There is increasing evidence that stimuli‐responsive nanomaterials have become significantly critical components of modern materials design and technological developments. Recent advances in synthesis and fabrication of stimuli‐responsive polymeric nanoparticles with built‐in stimuli‐responsive components (Part A) and surface modifications of functional nanoparticles that facilitate responsiveness (Part B) are outlined here.
2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions.
As we have seen so far, reversible, stimuli-responsive self-assembly.
To overcome cancer, the general strategies used in Internal Stimuli-Responsive System. Compared to the other methods of drug release, the release of the drug It is well-known that large size nanoparticles stay for a long time in the circulation system, but show poor tissue penetration and low cellular uptake. In order to reconcile the conflicting needs for extended circulation time, extensive tumor tissue penetration, and enhanced cellular uptake for nanodrug delivery systems, we designed DOX-containing hypersensitive nanoparticles that responded This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy.